Products:
Sphingosine-1-phosphate(S1P)lyasecatalyzestheirreversibledecompositionofS1Ptohexadecanaldehydeandphosphoethanolamine.2-Acetyl-5-tetrahydroxybutylimidazole(THI)isaninhibitorofS1Plyase.1BecauseS1Plyaseisprimarilyexpressedinlymphatictissue,treatmentofmicewithTHI(50µg/mlindrinkingwater)increaseslymphoidtissueS1Pconcentrations100-fold,reducinglymphocyteegressfromthymusandperipherallymphoidorgans.1,2TheresultinglymphopeniaisreversiblefollowingcessationofTHItreatment.3ReducingS1Plyaseactivityresultsintherapeuticlevelsofimmunosuppressionwithoutthenon-lymphoidlesionsthatresultfromsyntheticS1Preceptoragonists.4
1.Schwab,S.R.,Pereira,J.P.,Matloubian,M.,etal.LymphocytesequestrationthroughS1PlyaseinhibitionanddisruptionofS1Pgradients.Science309,1735-1739(2005).
2.Gugasyan,R.,Coward,A.,O’Connor,L.,etal.EmigrationofmatureTcellsfromthethymusisinhibitedbytheimidazole-basedcompound2-acetyl-4-tetrahydroxybutylimidazole.Immunology
93,398-404(1998).
93,398-404(1998).
3.Bradbury,M.G.,Doherty,K.V.,Parish,C.R.,etal.Theimmunosuppressivecompound2-acetyl-4-tetrahydroxybutylimidazoleinhibitstheallogeneicmixedlymphocytereactionbysequestrationofarecirculatingsubpopulationofTcells.Immunology87,80-85(1996).
4.Vogel,P.,Donoviel,M.S.,Read,R.,etal.Incompleteinhibitionofsphingosine1-phosphatelyasemodulatesimmunesystemfunctionyetpreventsearlylethalityandnon-lymphoidlesions.
PLoSOne4(1),(2009).
PLoSOne4(1),(2009).
Data:
- MolecularFormula
- C9H14N2O5
- PercentComposition
- C46.95%,H6.13%,N12.17%,O34.75%
- Purity
- >98%
- Stability
- 1Years
- Storage
- -20°C
- CASNumber
- 94944-70-4
CASRegistryNumberisaRegisteredTrademarkoftheAmericanChemicalSociety - MolecularWeight
- 230.218
- ExactMass
- 230.090
- Synonyms
- 2-acetyl-4-tetrahydroxybutylimidazole2-acetyl-4(5)-tetrahydroxybutylimidazole2-ATHBI