Avanti Polar Lipids/THI / 857393/1 x 10mg

Products:

Sphingosine-1-phosphate(S1P)lyasecatalyzestheirreversibledecompositionofS1Ptohexadecanaldehydeandphosphoethanolamine.2-Acetyl-5-tetrahydroxybutylimidazole(THI)isaninhibitorofS1Plyase.¹BecauseS1Plyaseisprimarilyexpressedinlymphatictissue,treatmentofmicewithTHI(50µg/mlindrinkingwater)increaseslymphoidtissueS1Pconcentrations100-fold,reducinglymphocyteegressfromthymusandperipherallymphoidorgans.^1,2TheresultinglymphopeniaisreversiblefollowingcessationofTHItreatment.³ReducingS1Plyaseactivityresultsintherapeuticlevelsofimmunosuppressionwithoutthenon-lymphoidlesionsthatresultfromsyntheticS1Preceptoragonists.⁴

 

1.Schwab,S.R.,Pereira,J.P.,Matloubian,M.,etal.LymphocytesequestrationthroughS1PlyaseinhibitionanddisruptionofS1Pgradients.Science309,1735-1739(2005).

 

2.Gugasyan,R.,Coward,A.,O’Connor,L.,etal.EmigrationofmatureTcellsfromthethymusisinhibitedbytheimidazole-basedcompound2-acetyl-4-tetrahydroxybutylimidazole.Immunology
93,398-404(1998).

 

3.Bradbury,M.G.,Doherty,K.V.,Parish,C.R.,etal.Theimmunosuppressivecompound2-acetyl-4-tetrahydroxybutylimidazoleinhibitstheallogeneicmixedlymphocytereactionbysequestrationofarecirculatingsubpopulationofTcells.Immunology87,80-85(1996).

 

4.Vogel,P.,Donoviel,M.S.,Read,R.,etal.Incompleteinhibitionofsphingosine1-phosphatelyasemodulatesimmunesystemfunctionyetpreventsearlylethalityandnon-lymphoidlesions.
PLoSOne4(1),(2009).

Data:

MolecularFormula

C₉H₁₄N₂O₅

PercentComposition

C46.95%,H6.13%,N12.17%,O34.75%

Purity

>98%

Stability

1Years

Storage

-20°C

CASNumber

94944-70-4
CASRegistryNumberisaRegisteredTrademarkoftheAmericanChemicalSociety

MolecularWeight

230.218

ExactMass

230.090

Synonyms

2-acetyl-4-tetrahydroxybutylimidazole

2-acetyl-4(5)-tetrahydroxybutylimidazole

2-ATHBI