Products:

Sphingosine-1-phosphate(S1P)lyasecatalyzestheirreversibledecompositionofS1Ptohexadecanaldehydeandphosphoethanolamine.2-Acetyl-5-tetrahydroxybutylimidazole(THI)isaninhibitorofS1Plyase.1BecauseS1Plyaseisprimarilyexpressedinlymphatictissue,treatmentofmicewithTHI(50µg/mlindrinkingwater)increaseslymphoidtissueS1Pconcentrations100-fold,reducinglymphocyteegressfromthymusandperipherallymphoidorgans.1,2TheresultinglymphopeniaisreversiblefollowingcessationofTHItreatment.3ReducingS1Plyaseactivityresultsintherapeuticlevelsofimmunosuppressionwithoutthenon-lymphoidlesionsthatresultfromsyntheticS1Preceptoragonists.4
 
1.Schwab,S.R.,Pereira,J.P.,Matloubian,M.,etal.LymphocytesequestrationthroughS1PlyaseinhibitionanddisruptionofS1Pgradients.Science309,1735-1739(2005).
 
2.Gugasyan,R.,Coward,A.,O’Connor,L.,etal.EmigrationofmatureTcellsfromthethymusisinhibitedbytheimidazole-basedcompound2-acetyl-4-tetrahydroxybutylimidazole.Immunology
93,398-404(1998).
 
3.Bradbury,M.G.,Doherty,K.V.,Parish,C.R.,etal.Theimmunosuppressivecompound2-acetyl-4-tetrahydroxybutylimidazoleinhibitstheallogeneicmixedlymphocytereactionbysequestrationofarecirculatingsubpopulationofTcells.Immunology87,80-85(1996).
 
4.Vogel,P.,Donoviel,M.S.,Read,R.,etal.Incompleteinhibitionofsphingosine1-phosphatelyasemodulatesimmunesystemfunctionyetpreventsearlylethalityandnon-lymphoidlesions.
PLoSOne4(1),(2009).

Data:

MolecularFormula
C9H14N2O5
PercentComposition
C46.95%,H6.13%,N12.17%,O34.75%
Purity
>98%
Stability
1Years
Storage
-20°C
CASNumber
94944-70-4
CASRegistryNumberisaRegisteredTrademarkoftheAmericanChemicalSociety
MolecularWeight
230.218
ExactMass
230.090
Synonyms
2-acetyl-4-tetrahydroxybutylimidazole
2-acetyl-4(5)-tetrahydroxybutylimidazole
2-ATHBI