Hongbin Xu

Frederic R. Boucher

Thao T Nguyen[...]

Steffany A.L. BennettCerebrosides, including glucosylceramides (GlcCer) and galactosylceramides (GalCer), are important membrane components of animal cells with deficiencies resulting in devastating lysosomal storage disorders. Their quantification is essential for disease diagnosis and a better understanding of disease mechanisms. Simultaneous quantification of GlcCer...ViewThe interaction of lipid-liganded gold clusters (Aurora TM) with lipid bilayersArticleNov 2018

Jesús Sot

Sebastião Mendanha

Jon V. Busto[...]

Alicia AlonsoLipid bilayers of different phospholipid compositions have been prepared, in the form of vesicles, or of supported lipid bilayers, and doped with Aurora™ at 0.1 mol%. Aurora™ consists of an Au55 gold nanoparticle (about 1.4 nm in diameter) capped with triphenylphosphine ligands and a single diglyceride (distearoyl glycerol) ligand. Gold nanoparticl...ViewImpact of Fabp1 Gene Ablation on Uptake and Degradation of Endocannabinoids in Mouse HepatocytesArticleSep 2018

Avery Mcintosh

Huan Huang

Danilo Landrock[...]

Friedhelm SchroederLiver fatty‐acid‐binding protein (FABP1, L‐FABP) is the major cytosolic binding/chaperone protein for both precursor arachidonic acid (ARA) and the endocannabinoid (EC) products N‐arachidonoylethanolamine (AEA) and 2‐arachidonoylglycerol (2‐AG). Although FABP1 regulates hepatic uptake and metabolism of ARA, almost nothing is known regarding FABP1’s...ViewSynthesis, characterization and reactions of [RhCl(CO){(Ph2P(CH2CH2O)mCH2CH2Ph2-P,P’)}]n (m = 3, 4, 5 n = 1, 2 …) metallacrown crown ethersArticleSep 2018

Dale Clark Smith

Ethan C. Cagle

Gary GrayThe reactions of [RhCl(cod)]2 and Ph2P(CH2CH2O)nCH2CH2PPh2P (n = 3, 4, 5) under a CO atmosphere yield [RhCl(CO){(Ph2P(CH2CH2O)n CH2CH2Ph2-P,P′)}]m monocarbonyl metallacrown ethers. These complexes are mixtures of cyclic n-mers and monomers with trans coordination geometries at the rhodium. The monocarbonyl rhodium metallacrown ethers reversibly rea...ViewA novel system to quantify intestinal lipid digestion and transportArticleFull-text availableMay 2018

Øystein Saele

Kari Elin L. Rød

Vanessa Quinlivan[...]

Steven A FarberThe zebrafish larva is a powerful tool for the study of dietary triglyceride (TG) digestion and how fatty acids (FA) derived from dietary lipids are absorbed, metabolized and distributed to the body. While fluorescent FA analogues have enabled visualization of FA metabolism, methods for specifically assaying TG digestion are badly needed. Here we p...ViewLPS-induced cytokine storm produces QTc prolongation which can be prevented by an anti-inflammatory eutectic blendArticleSep 2016

Annie Bouchard

Peter P Sordillo

Lawrence Helson[...]

Dany SalvailViewFABP1: A Novel Hepatic Endocannabinoid and Cannabinoid Binding ProteinArticleAug 2016

Huan Huang

Avery Mcintosh

Gregory G Martin[...]

Friedhelm SchroederEndocannabinoids (EC) and cannabinoids are very lipophilic molecules requiring the presence of cytosolic binding proteins that chaperone these molecules to intracellular targets. While three different fatty acid binding proteins (FABP3, 5, 7) serve this function in brain, relatively little is known about how such hydrophobic EC and cannabinoids are...ViewTuning Ciprofloxacin Release Profiles from Liposomally Encapsulated Nanocrystalline DrugArticleFull-text availableJul 2016

David Cipolla

Huiying Wu

Simon Eastman[...]

Hak-Kim ChanPurpose: In order to attenuate the drug release rate, a single freeze-thaw step was previously shown to convert encapsulated drug into a single nanocrystal within each liposome vesicle. The goal of this study was to alter the nanocrystalline character, and thus the drug encapsulation state and release profile, by addition of surfactant prior to fr...ViewFatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: roles in the endocannabinoid system and dyslipidemiasArticleFull-text availableApr 2016

Friedhelm Schroeder

Avery Mcintosh

Gregory G Martin[...]

Ann B KierThe first discovered member of the mammalian FABP family, liver fatty acid binding protein (FABP1, L-FABP), occurs at high cytosolic concentration in liver, intestine, and in the case of humans also in kidney. While the rat FABP1 is well studied, the extent these findings translate to human FABP1 is not clear-especially in view of recent studies sh...ViewFormation of Drug Nanocrystals under Nanoconfinement Afforded by LiposomesArticleFull-text availableJan 2016

David Cipolla

Huiying Wu

Stefan Salentinig[...]

Hak-Kim ChanNanocrystals of drug substances have important therapeutic applications, but their preparation is often difficult due to size control in bottom up approaches, or energetic milling and surface activation in top down processing. In this study, confinement within liposome nanocompartments is demonstrated to enable drug crystallization with a high aspe...ViewBiophysical Properties of Novel 1-Deoxy-(Dihydro)ceramides Occurring in Mammalian CellsArticleDec 2014

Noemi Jiménez-Rojo

Jesús Sot

Jon V Busto[...]

Félix M GoñiCeramides and dihydroceramides are N-acyl derivatives of sphingosine and sphinganine, respectively, which are the major sphingoid-base backbones of mammals. Recent studies have found that mammals, like certain other organisms, also produce 1-deoxy-(dihydro)ceramides (1-deoxyDHCers) that contain sphingoid bases lacking the 1-hydroxyl- or 1-hydroxyme...ViewA Rapid Ceramide Synthase Activity using NBD-sphinganine and Solid Phase Extraction.ArticleNov 2014

Rotem Tidhar

Kacee H. Sims

Eden Rosenfeld-Gur[...]

Anthony H FutermanCeramides are synthesized by six mammalian ceramide synthases (CerS), each of which uses fatty acyl CoAs of different chain lengths for N-acylation of the sphingoid long chain base. We now describe a rapid and reliable CerS assay that uses a fluorescent (NBD) sphinganine substrate followed by separation of the NBD-lipid substrate and products using...ViewDevelopment of a rapid capture-cum-detection method for Escherichia coli O157 from apple juice comprising nano-immunomagnetic separation in tandem with surface enhanced Raman scatteringArticleAug 2014

Roya Najafi

Shubhasish Mukherjee

Jim Hudson[...]

Pratik BanerjeeA combined capture and detection method comprising of nano-immunomagnetic separation (NIMS) and surface enhanced Raman spectroscopy (SERS) was developed to detect Escherichia coli O157 from liquid media including apple juice. The capture antibodies (cAbs) were immobilized on magnetite-gold (Fe3O4/Au) magnetic nanoparticles (MNPs) which were used fo...ViewAvanti lipid tools: Connecting lipids, technology, and cell biologyArticleAug 2014

Kacee H. Sims

Ewan M Tytler

John Tipton[...]

Walter A ShawLipid research is challenging owing to the complexity and diversity of the lipidome. Here we review a set of experimental tools developed for the seasoned lipid researcher, as well as, those who are new to the field of lipid research. Novel tools for probing protein-lipid interactions, applications for lipid binding antibodies, enhanced systems for...ViewSphingosine induces the aggregation of imine-containing peroxidized vesiclesArticleMay 2014

Noemi Jiménez-Rojo

Ana R Viguera

Isabel Collado[...]

Alicia AlonsoLipid peroxidation plays a central role in the pathogenesis of many diseases like atherosclerosis and multiple sclerosis. We have analyzed the interaction of sphingosine with peroxidized bilayers in model membranes. Cu(2+) induced peroxidation was checked following UV absorbance at 245nm, and also using the novel Avanti snoopers®. Mass spectrometry...View1-O-Acylceramides are natural components of human and mouse epidermis.ArticleFull-text availableSep 2013

Mariona Rabionet

Aline Bayerle

Christian Marsching[...]

Roger SandhoffThe lipid-rich stratum corneum functions as a barrier against pathogens and desiccation inter alia by an unbroken meshwork of extracellular lipid lamellae. These lamellae are composed of cholesterol, fatty acids and ceramides in an equimolar ratio. The huge class of skin ceramides consists of 3 groups, I) classical long and very long chain cerami...ViewEffect of oral administration of soy-derived phosphatidic acid on concentrations of phosphatidic acid and lyso-phosphatidic acid molecular species in human plasmaConference PaperFull-text availableJun 2013

Martin Purpura

Ralf Jäger

Jordan M Joy[...]

Jacob M WilsonBackgroundThe glycerophospholipid Phosphatidic acid (PA) has been identified as a potential nutritional treatment for gastrointestinal disorders. Dietary food sources rich in PA include cabbage and radish leaves as well as Mallotus japonicas, a Japanese edible herb historically used for the treatment of stomach ulcers. The mammalian target of rapa...ViewStandardization and Quantification of Lysophosphatidic Acid Compounds by Normal-Phase and Reversed-Phase Chromatography-Tandem Mass SpectrometryChapterFull-text availableFeb 2013

Jeff D Moore

Shengrong Li

David S. Myers[...]

Walter A ShawViewGravimetric determination of phospholipid concentrationArticleFull-text availableJul 2012

Roberto Tejera-Garcia

Lisa Connell

Walter A Shaw

Paavo KJ KinnunenAccurate determination of lipid concentrations is an obligatory routine in a research laboratory engaged in studies using this class of biomaterials. For phospholipids, this is frequently accomplished using the phosphate assay (Bartlett, G.R. Phosphorus Assay in Column Chromatography. J. Biol. Chem. 234, 466-468, 1959). Given the purity of the curr...ViewIn Vivo Detection of Oxidation-Specific Epitopes in Atherosclerotic Lesions Using Biocompatible Manganese Molecular Magnetic Imaging ProbesArticleFeb 2012

Karen Briley

Tuyen Nguyen

Alexander M Saeboe[...]

Sotirios TsimikasThis study sought to evaluate the in vivo magnetic resonance imaging (MRI) efficacy of manganese [Mn(II)] molecular imaging probes targeted to oxidation-specific epitopes (OSE).OSE are critical in the initiation, progression, and destabilization of atherosclerotic plaques. Gadolinium [Gd(III)]-based MRI agents can be associated with systemic toxic...ViewInformation provided on this web page is aggregated encyclopedic and bibliographical information relating to the named institution. Information provided is not approved by the institution itself. The institution’s logo (and/or other graphical identification, such as a coat of arms) is used only to identify the institution in a nominal way. Under certain jurisdictions it may be property of the institution.20 membersView allPaul R S BakerAnalytical DivisionWalter A ShawShengrong LiR DStephen W BurgessEwan M TytlerLipidomicsInformationAddressAlabaster, United StatesTop collaborating institutionsUniversity of Alabama at Birmingham7,058 MembersUniversity of California, San Diego17,044 MembersCompanyAbout usNewsCareersSupportHelp CenterBusiness solutionsAdvertisingRecruiting© 2008-2020 ResearchGate GmbH. All rights reserved.TermsPrivacyCopyrightImprint

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