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主营 1000 种以上脂类产品、磷脂类和甾体类中间体、试剂等
℡ 4000-520-616
℡ 4000-520-616
avanti polar lipids/4ME 16:0 Diether DG/5mg/999986O-5mg
产品编号:999986O-5mg
市  场 价:¥4144.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$207.20
品      牌: avanti polar lipids
公      司:Avanti Lipids Polar, Inc.
公司分类:
avanti polar lipids/4ME 16:0 Diether DG/5mg/999986O-5mg
商品介绍

999986 | 4ME 16:0 Diether DG

1,2-di-O-phytanyl-sn-glycerol

4ME 16:0 Diether DG
Info

4ME 16:0 Diether DG

1,2-di-O-phytanyl-sn-glycerol

In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane. (See References) Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.

Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.

Storage:Diacylglycerols are conveniently stored in chloroform solutions in glass vials with teflon-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

Delivery to cells:Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.

Effective concentration:Most biological responses saturate at 20 to 250 µM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C43H88O3
Percent Composition
C 79.07%, H 13.58%, O 7.35%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
99341-19-2 CAS Registry Number is a Registered Trademark of the American Chemical Society
FormulaWeight
653.157
Exact Mass
652.673
Synonyms
<p>archaeol1,2-di-(3,7,11,15-tetramethylhexadecyl)-sn-glycerolDG(16:0(3me,7me,11me,15me)e/16:0(3me,7me,11me,15me)e)/0:0)</p>
Downloads
  • ChemDraw File
  • 3D Structure
  • Structure
  • Safety Data Sheet
  • Safety Data Sheet
References

Iaea DB, Spahr ZR, Singh RK, Chan RB, Zhou B, Bareja R, Elemento O, Di Paolo G, Zhang X, Maxfield FR. Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr;1865(4):158609. doi: 10.1016/j.bbalip.2020.158609. Epub 2020 Jan 7. PMID: 31917335; PMCID: PMC6996790.

PubMed ID: 31917335

Meyer S, Thiel V, Joergensen RG, Sundrum A. Relationships between feeding and microbial faeces indices in dairy cows at different milk yield levels. PLoS One. 2019 Aug 20;14(8):e0221266. doi: 10.1371/journal.pone.0221266. eCollection 2019.

PubMed ID: 31430322

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Certificates of Analysis
  • Certificate of Analysis(Lot No. 999986C-50MG-A-013and 6396OKA013)
  • Certificate of Analysis(Lot No. 999986C-5MG-A-013and 6396CHA013)
  • Certificate of Analysis(Lot No. 999986O-50MG-A-013and 6396OKA013)
  • Certificate of Analysis(Lot No. 999986O-5MG-A-013and 6396OHA013)
  • Certificate of Analysis(Lot No. 999986C-200MG-A-013and 6396CNA013)
  • Certificate of Analysis(Lot No. 999986O-200MG-A-013and 6396ONA013)
  • Certificate of Analysis(Lot No. 999986O-200MG-B-013and 6396ONB013)
  • Certificate of Analysis(Lot No. 999986C-5MG-B-013and 6396CHB013)
  • Certificate of Analysis(Lot No. 999986O-5MG-A-014and 6396OHA014)
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品牌介绍

Avanti Polar Lipids.jpg


Avanti Polar Lipids公司是美国著名的磷脂类产品的生产商,该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供 1000 种以上脂类产品,由于其产品的高纯度而享誉全球。40年来,Avanti Polar Lipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大,其纯度之高也是无人能及。

 

Avanti Polar Lipids, Inc., has a long history of 50 years creating the highest purity lipids available. Our passion for high quality and unique products is only exceeded by our excellent reputation in the marketplace. Although we are known for our lipids, we are More than Lipids. We offer solutions for the entire product cycle…Research to Commercialization.

 

Avanti Polar Lipids公司的主要产品和服务包括:

(1)Research Products

Highest Purity Lipid Reagents

(2)cGMP Manufacturing

API & Contract Manufacturing

(3)Adjuvants

Immunotherapy & Vaccine Development

(4)Analytical Services

Lipid Analysis

(5)Lipidomics

Mass Spec Standards, Antibodies & Lipid Toolbox

(6)Formulations

Liposomes & Nanoparticles

(7)Equipment

Liposome Production Tools

(8)Custom Services

Synthesis & Beyond

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