β-sitosterol is a phytosterol (plant sterol) found in a wide variety of plants such as pecans, saw palmetto, avocados, pumpkin seed, rice bran, wheat germ, and soybeans. Recently, sitosterol has been investigated as a substitute for cholesterol in lipid-based mRNA delivery systems. In 2020, it was reported that β-sitosterol-substituted lipid nanoparticle (LNPs) maintained comparable size and encapsulation but were considerably more effective at mRNA transfection than LNPs containing cholesterol (Patel, 2020). Purchase Avanti"s sitosterol today to fuel your therapeutics delivery research.
C29H50O
C 83.99%, H 12.15%, O 3.86%
Patel S, Ashwanikumar N, Robinson E, Xia Y, Mihai C, Griffith JP 3rd, Hou S, Esposito AA, Ketova T, Welsher K, Joyal JL, Almarsson Ö, Sahay G. Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA. Nat Commun. 2020 Feb 20;11(1):983. doi: 10.1038/s41467-020-14527-2. Erratum in: Nat Commun. 2020 Jul 6;11(1):3435. PMID: 32080183; PMCID: PMC7033178.
Avanti Polar Lipids公司是美国著名的磷脂类产品的生产商,该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供 1000 种以上脂类产品,由于其产品的高纯度而享誉全球。40年来,Avanti Polar Lipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大,其纯度之高也是无人能及。
Avanti Polar Lipids, Inc., has a long history of 50 years creating the highest purity lipids available. Our passion for high quality and unique products is only exceeded by our excellent reputation in the marketplace. Although we are known for our lipids, we are More than Lipids. We offer solutions for the entire product cycle…Research to Commercialization.
Avanti Polar Lipids公司的主要产品和服务包括:
(1)Research Products
Highest Purity Lipid Reagents
(2)cGMP Manufacturing
API & Contract Manufacturing
(3)Adjuvants
Immunotherapy & Vaccine Development
(4)Analytical Services
Lipid Analysis
(5)Lipidomics
Mass Spec Standards, Antibodies & Lipid Toolbox
(6)Formulations
Liposomes & Nanoparticles
(7)Equipment
Liposome Production Tools
(8)Custom Services
Synthesis & Beyond