Ent-Androstenediol

Ent-Androstenediol

Ent-Androstenediol is an enantiomer of the hormone androstenediol.

Enantiomers, also called optical isomers, are a type of stereoisomers that are mirror images of one another, meaning they have the same connectivity but opposite three-dimensional shapes. The only way they are distinguished is their ability to rotate plane-polarized light (+/−) by equal amounts but in opposite directions. Except for that, they have identical chemical properties.

The steroid hormone androstenediol is found in the cortex of the adrenal glands. It’s a direct metabolite of DHEA (dehydroepiandrosterone). The compound is derived from DHEA as a result of a reduction of the 17-keto group. Androstenediol is a precursor of the major male sex hormone testosterone. The process through which androstenediol is converted to testosterone is the oxidation of the 3-β hydroxyl group to a 3-keto group by the enzyme 3-hydroxysteroid dehydrogenase.

Androstenediol actually has minimal androgenic activity but is known to have immunostimulatory effects. The hormone has been studied to enhance the differentiation of hematopoietic precursor cells into leukocytes and platelets.

This particular property of the compound has been the base of investigation of androstenediol for use as a radiation countermeasure in radiation exposure.

Its enantiomer, Ent-Androstenediol, acts as a suitable alternative to incorporate in various studies into the roles and effects of androstenediol.

Avanti’s quality and pure Ent-Androstenediol supports reliable research outcomes.

• ChemDraw File
• 3D Structure
• Structure
• Safety Data Sheet