avanti polar lipids/MVL5/5mg/890000P-5mg,avanti polar lipids,,Avanti Polar,Avanti,avantilipids,Avanti Polar Lipids Inc,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：avanti polar lipids/MVL5/5mg/890000P-5mg

产品编号：890000P-5mg

市场价：¥19135.00

场地：美国(厂家直采)

产品分类：分子类>核酸酶类>其他>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$956.75

品牌： avanti polar lipids

公司：Avanti Lipids Polar, Inc.

公司分类：

商品介绍

890000 | MVL5

N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide

Info

MVL5

N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide

New Multivalent Cationic Lipid for siRNA Delivery

• Improved total gene silencing• Lower non-specific gene silencing• Lower toxicity

These attributes establish the multivalent MVL5 as a superior transfection vector for siRNAs, and have implications for the optimal use of cationic lipids in therapeutic applications.

Now available as a pre-mixed kit, MVL5 and GMO ready to use.Avanti Number 640009

Data

Hygroscopic

Light Sensitive

Molecular Formula

C₅₉H₁₁₆Cl₅N₇O₄

Percent Composition

C 60.83%, H 10.04%, Cl 15.22%, N 8.42%, O 5.49%

Purity

>99%

Stability

1 Year

Storage Temperature

-20°C

CAS Number

464926-03-2 CAS Registry Number is a Registered Trademark of the American Chemical Society

FormulaWeight

1164.862

Exact Mass

1161.754

Synonyms

N1,N1,N4-tris(3-ammoniopropyl)-5-((2-(3,4-bis((Z)-octadec-9-en-1-yloxy)benzamido)ethyl)amino)-5-oxopentane-1,4-diaminium chloride

Downloads

ChemDraw File
3D Structure
Structure
Safety Data Sheet

References

Ravi V, Madhankumar AB, Abraham T, Slagle-Webb B, Connor JR. Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms. PLoS One. 2019 Sep 6;14(9):e0221952. doi: 10.1371/journal.pone.0221952. eCollection 2019.

PubMed ID: 31491006

Guevara ML, Jilesen Z, Stojdl D, Persano S. Codelivery of mRNA with α-Galactosylceramide Using a New Lipopolyplex Formulation Induces a Strong Antitumor Response upon Intravenous Administration. ACS Omega. 2019 Aug 7;4(8):13015-13026. doi: 10.1021/acsomega.9b00489. eCollection 2019 Aug 20.

PubMed ID: 31460428

Chan CL, Ewert KK, Majzoub RN, Hwu YK, Liang KS, Leal C, Safinya CR. Optimizing cationic and neutral lipids for efficient gene delivery at high serum content. J Gene Med. 2014 Mar-Apr;16(3-4):84-96. doi: 10.1002/jgm.2762.

PubMed ID: 24753287

Leal C, Ewert KK, Shirazi RS, Bouxsein NF, Safinya CR. Nanogyroids incorporating multivalent lipids: enhanced membrane charge density and pore forming ability for gene silencing. Langmuir. 2011 Jun 21;27(12):7691-7. doi: 10.1021/la200679x. Epub 2011 May 25.

PubMed ID: 21612245

Bouxsein NF, McAllister CS, Ewert KK, Samuel CE, Safinya CR. Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA. Biochemistry. 2007 Apr 24;46(16):4785-92. Epub 2007 Mar 29.

PubMed ID: 17391006

Ewert K, Ahmad A, Evans HM, Schmidt HW, Safinya CR. Efficient synthesis and cell-transfection properties of a new multivalent cationic lipid for nonviral gene delivery. J Med Chem. 2002 Nov 7;45(23):5023-9.

PubMed ID: 12408712

Certificates of Analysis

Certificate of Analysis(Lot No. 890000P-1MG-A-010and 6343PGA010)
Certificate of Analysis(Lot No. 890000P-1MG-B-010and 6343PGB010)
Certificate of Analysis(Lot No. 890000P-1MG-D-010and 6343PGD010)
Certificate of Analysis(Lot No. 890000P-1MG-E-010and 6343PGE010)
Certificate of Analysis(Lot No. 890000P-10MG-A-010and 6343PIA010)
Certificate of Analysis(Lot No. 890000P-1MG-F-010and 6343PGF010)
Certificate of Analysis(Lot No. 890000P-1MG-G-010and 6343PGG010)
Certificate of Analysis(Lot No. 890000P-5MG-A-011and 6343PHA011)
Certificate of Analysis(Lot No. 890000P-5MG-A-012and 6343PHA012)

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品牌介绍

Avanti Polar Lipids.jpg

Avanti Polar Lipids公司是美国著名的磷脂类产品的生产商，该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供 1000 种以上脂类产品，由于其产品的高纯度而享誉全球。40年来，Avanti Polar Lipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大，其纯度之高也是无人能及。

Avanti Polar Lipids, Inc., has a long history of 50 years creating the highest purity lipids available. Our passion for high quality and unique products is only exceeded by our excellent reputation in the marketplace. Although we are known for our lipids, we are More than Lipids. We offer solutions for the entire product cycle…Research to Commercialization.

Avanti Polar Lipids公司的主要产品和服务包括：

（1）Research Products

Highest Purity Lipid Reagents

（2）cGMP Manufacturing

API & Contract Manufacturing

（3）Adjuvants

Immunotherapy & Vaccine Development

（4）Analytical Services

Lipid Analysis

（5）Lipidomics

Mass Spec Standards, Antibodies & Lipid Toolbox

（6）Formulations