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主营 1000 种以上脂类产品、磷脂类和甾体类中间体、试剂等
℡ 4000-520-616
℡ 4000-520-616
avanti polar lipids/22:0 Trehalose/5mg/890808P-5mg
产品编号:890808P-5mg
市  场 价:¥7104.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>多肽合成>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$355.20
品      牌: avanti polar lipids
公      司:Avanti Lipids Polar, Inc.
公司分类:
avanti polar lipids/22:0 Trehalose/5mg/890808P-5mg
商品介绍

890808 | 22:0 Trehalose

D-(+)-trehalose 6,6"-dibehenate

22:0 Trehalose
Info

22:0 Trehalose

D-(+)-trehalose 6,6"-dibehenate

Incorporation of the glycolipid trehalose 6,6"-dibehenate (TDB) into cationic liposomes composed of the quaternary ammonium compound dimethyldioctadecylammonium (DDA) produce an adjuvant system which induces a powerful cell-mediated immune response and a strong antibody response, desirable for a high number of disease targets.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C56H106O13
Percent Composition
C 68.12%, H 10.82%, O 21.06%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
66758-35-8 CAS Registry Number is a Registered Trademark of the American Chemical Society
FormulaWeight
987.433
Exact Mass
986.763
Synonyms
TDB6,6'-didocosanoyl-α,α'-trehalose
Downloads
  • ChemDraw File
  • 3D Structure
  • Structure
  • Brochure
  • Safety Data Sheet
References

Teng X, Tian M, Li J, Tan S, Yuan X, Yu Q, Jing Y, Zhang Z, Yue T, Zhou L, Fan X. Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine. Hum Vaccin Immunother. 2015;11(6):1456-64. doi: 10.1080/21645515.2015.1037057. PMID: 25905680; PMCID: PMC4514263.

PubMed ID: 25905680

Rose F, Wern JE, Ingvarsson PT, van de Weert M, Andersen P, Follmann F, Foged C. Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: A quality-by-design approach. J Control Release. 2015 Jul 28;210:48-57. doi: 10.1016/j.jconrel.2015.05.004. Epub 2015 May 6. PMID: 25957906.

PubMed ID: 25957906

Derrick SC, Yabe I, Morris S, Cowley S. Induction of Unconventional T Cells by a Mutant Mycobacterium bovis BCG Strain Formulated in Cationic Liposomes Correlates with Protection against Mycobacterium tuberculosis Infections of Immunocompromised Mice. Clin Vaccine Immunol. 2016 Jul 5;23(7):638-47. doi: 10.1128/CVI.00232-16. PMID: 27226281; PMCID: PMC4933783.

PubMed ID: 27226281

Larrouy-Maumus G, Layre E, Clark S, Prandi J, Rayner E, Lepore M, de Libero G, Williams A, Puzo G, Gilleron M. Protective efficacy of a lipid antigen vaccine in a guinea pig model of tuberculosis. Vaccine. 2017 Mar 7;35(10):1395-1402. doi: 10.1016/j.vaccine.2017.01.079. Epub 2017 Feb 9. PMID: 28190740.

PubMed ID: 28190740

Hansen M, Peltier J, Killy B, Amin B, Bodendorfer B, Härtlova A, Uebel S, Bosmann M, Hofmann J, Büttner C, Ekici AB, Kuttke M, Franzyk H, Foged C, Beer-Hammer S, Schabbauer G, Trost M, Lang R. Macrophage phosphoproteome analysis reveals MINCLE-dependent and -independent mycobacterial cord factor signaling. Mol Cell Proteomics. 2019 Jan 11. pii: mcp.RA118.000929. doi: 10.1074/mcp.RA118.000929. [Epub ahead of print]

PubMed ID: 30635358

Fomsgaard, A., Karlsson, I., Gram, G., Schou, C., Tang, S., Bang, P., Kromann, I., Andersen, P., Andreasen, L.V. (2011) Development and preclinical safety evaluation of a new therapeutic HIV-1 vaccine based on 18 T-cell minimal epitope peptides applying a novel cationic adjuvant CAF01. Vaccine. 29:7067-74.

PubMed ID: 21767590

Nordly, P., Agger, E.M., Andersen, P., Nielsen, H.M., Foged, C. (2011) Incorporation of the TLR4 agonist monophosphoryl lipid A into the bilayer of DDA/TDB liposomes: physico-chemical characterization and induction of CD8+ T-cell responses in vivo. Pharm Res. 28:553-62.

PubMed ID: 21042837

Gram, G.J., Karlsson, I., Agger, E.M., Andersen, P., Fomsgaard, A. (2009) A novel liposome-based adjuvant CAF01 for induction of CD8(+) cytotoxic T-lymphocytes (CTL) to HIV-1 minimal CTL peptides in HLA-A*0201 transgenic mice. PLoS One. 4:e6950.

PubMed ID: 19759892

Davidsen, J., Rosenkrands, I., Christensen, D., Vangala, A., Kirby, D., Perrie, Y., Agger, E.M., Andersen, P. (2005) Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6"-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses. Biochim Biophys Acta. 1718:22-31.

PubMed ID: 16321607
Certificates of Analysis
  • Certificate of Analysis(Lot No. 890808P-25MG-A-017and 6351PJA017)
  • Certificate of Analysis(Lot No. 890808P-5MG-A-017and 6351PHA017)
  • Certificate of Analysis(Lot No. 890808P-25MG-B-017and 6351PJB017)
  • Certificate of Analysis(Lot No. 890808P-5MG-B-017and 6351PHB017)
  • Certificate of Analysis(Lot No. 890808P-5MG-C-017and 6351PHC017)
  • Certificate of Analysis(Lot No. 890808P-25MG-C-017and 6351PJC017)
  • Certificate of Analysis(Lot No. 890808P-5MG-D-017and 6351PHD017)
  • Certificate of Analysis(Lot No. 890808P-5MG-E-017and 6351PHE017)
  • Certificate of Analysis(Lot No. 890808P-5MG-F-017and 6351PHF017)
  • Certificate of Analysis(Lot No. 890808P-25MG-D-017and 6351PJD017)
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品牌介绍

Avanti Polar Lipids.jpg


Avanti Polar Lipids公司是美国著名的磷脂类产品的生产商,该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供 1000 种以上脂类产品,由于其产品的高纯度而享誉全球。40年来,Avanti Polar Lipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大,其纯度之高也是无人能及。

 

Avanti Polar Lipids, Inc., has a long history of 50 years creating the highest purity lipids available. Our passion for high quality and unique products is only exceeded by our excellent reputation in the marketplace. Although we are known for our lipids, we are More than Lipids. We offer solutions for the entire product cycle…Research to Commercialization.

 

Avanti Polar Lipids公司的主要产品和服务包括:

(1)Research Products

Highest Purity Lipid Reagents

(2)cGMP Manufacturing

API & Contract Manufacturing

(3)Adjuvants

Immunotherapy & Vaccine Development

(4)Analytical Services

Lipid Analysis

(5)Lipidomics

Mass Spec Standards, Antibodies & Lipid Toolbox

(6)Formulations

Liposomes & Nanoparticles

(7)Equipment

Liposome Production Tools

(8)Custom Services

Synthesis & Beyond

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