Lysophosphatidic acid (LPA) acts as an extracellular signaling molecule and activates LPA1-6 receptors. These receptors are of particular importance in the nervous, cardiovascular, reproductive, gastrointestinal, and pulmonary systems. AzoLPA is embedded with an azobenzene photoswitch which enables the optical control of LPA receptor activation. The light-induced cis- form shows greater activation of LPA receptors than its dark-adapted trans- form.
Morstein J, Dacheux MA, Norman DD, Shemet A, Donthamsetti PC, Citir M, Frank JA, Schultz C, Isacoff EY, Parrill AL, Tigyi GJ, Trauner D. Optical Control of Lysophosphatidic Acid Signaling. J Am Chem Soc. 2020 Jun 17;142(24):10612-10616. doi: 10.1021/jacs.0c02154. Epub 2020 Jun 5. PMID: 32469525.
C23H33N3O7P-
C 55.75%, H 6.92%, N 8.48%, O 22.60%, P 6.25%
Avanti Polar Lipids公司是美国著名的磷脂类产品的生产商,该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供 1000 种以上脂类产品,由于其产品的高纯度而享誉全球。40年来,Avanti Polar Lipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大,其纯度之高也是无人能及。
Avanti Polar Lipids, Inc., has a long history of 50 years creating the highest purity lipids available. Our passion for high quality and unique products is only exceeded by our excellent reputation in the marketplace. Although we are known for our lipids, we are More than Lipids. We offer solutions for the entire product cycle…Research to Commercialization.
Avanti Polar Lipids公司的主要产品和服务包括:
(1)Research Products
Highest Purity Lipid Reagents
(2)cGMP Manufacturing
API & Contract Manufacturing
(3)Adjuvants
Immunotherapy & Vaccine Development
(4)Analytical Services
Lipid Analysis
(5)Lipidomics
Mass Spec Standards, Antibodies & Lipid Toolbox
(6)Formulations
Liposomes & Nanoparticles
(7)Equipment
Liposome Production Tools
(8)Custom Services
Synthesis & Beyond