Nordeoxycholic Acid also known as 23-Nor-Deoxycholic Acid (23-Nor-DCA) is a steroid human metabolite with higher serum levels in women compared to men.
It’s a relative of the bile acid (BA) norcholic acid and a 23-carbon derivative of deoxycholic acid (DCA).
Norcholic acid is a minor BA found predominantly in human urine and meconium, while deoxycholic acid is one of the secondary BAs and an end product of the intestinal bacteria.
All BAs are important biomolecules, synthesized in the liver from cholesterol catabolism and responsible for the normal digestion and absorption of fats and other sterols. However, under certain pathological conditions, certain BAs can become prominent, and tend to show toxic effects on cells and tissues.
Levels of Norcholic acid, for instance, are increased in patients with cirrhosis and xanthomatosis - a metabolic disorder, characterized by mitochondrial enzyme sterol 27-hydrolase (CYP27A1) deficiency, that leads to progressive neurological symptoms.
As for the other parent compound of Nordeoxycholic Acid, DCA, it’s a BA with numerous effects in the human body, including emulsification of fats, preventing and dissolving gallstones, adipocytes destruction, and more.
As a BA, Nordeoxycholic Acid has similar effects, and it has also been found to decrease in models of rats on a high-fat diet, with a nonalcoholic fatty acid liver disease.
Additionally, Nordeoxycholic Acid is widely used as an internal standard for the quantification of bile acids.
Avanti’s Nordeoxycholic Acid is a high-quality bile acid for use in various types of bioanalyses research.
C23H38O4
C 72.98%, H 10.12%, O 16.91%
Avanti Polar Lipids公司是美国著名的磷脂类产品的生产商,该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供 1000 种以上脂类产品,由于其产品的高纯度而享誉全球。40年来,Avanti Polar Lipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大,其纯度之高也是无人能及。
Avanti Polar Lipids, Inc., has a long history of 50 years creating the highest purity lipids available. Our passion for high quality and unique products is only exceeded by our excellent reputation in the marketplace. Although we are known for our lipids, we are More than Lipids. We offer solutions for the entire product cycle…Research to Commercialization.
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