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产品名称：avanti polar lipids/12-NBD Stearate/1mg/810110P-1mg

产品编号：810110P-1mg

市场价：¥5469.40

场地：美国(厂家直采)

产品分类：生化试剂>生物分子>脂类>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$273.47

品牌： avanti polar lipids

公司：Avanti Lipids Polar, Inc.

公司分类：

商品介绍

810110 | 12-NBD Stearate

12-N-methyl-(7-nitrobenz-2-oxa-1,3-diazo)aminostearic acid

Info

12-NBD Stearate

12-N-methyl-(7-nitrobenz-2-oxa-1,3-diazo)aminostearic acid

NBD-stearate is a fluorescent fatty acid analogue used to probe fatty acid binding protein (FABP) and sterol carrier protein-2 (SCP-2).

Data

Hygroscopic

Light Sensitive

Yes

Molecular Formula

C₂₅H₄₀N₄O₅

Percent Composition

C 63.00%, H 8.46%, N 11.76%, O 16.78

Purity

>99%

Stability

1 Year

Storage Temperature

-20°C

CAS Number

117056-67-4 CAS Registry Number is a Registered Trademark of the American Chemical Society

FormulaWeight

476.609

Exact Mass

476.3

Downloads

ChemDraw File
3D Structure
Structure
Safety Data Sheet
Safety Data Sheet

References

Bai L, Parkin LA, Zhang H, Shum R, Previti ML, Seeliger JC. Dimethylaminophenyl Hydrazides as Inhibitors of the Lipid Transport Protein LprG in Mycobacteria. ACS Infect Dis. 2020 Mar 3. doi: 10.1021/acsinfecdis.9b00497. Epub ahead of print. PMID: 32053347.

PubMed ID: 32053347

Carbonetti G, Wilpshaar T, Kroonen J, Studholme K, Converso C, d"Oelsnitz S, Kaczocha M. FABP5 coordinates lipid signaling that promotes prostate cancer metastasis. Sci Rep. 2019 Dec 12;9(1):18944. doi: 10.1038/s41598-019-55418-x. PMID: 31831821; PMCID: PMC6908725.

PubMed ID: 31831821

Kim J, Bogdan DM, Elmes MW, Awwa M, Yan S, Che J, Lee G, Deutsch DG, Rizzo RC, Kaczocha M, Ojima I. Incarvillateine produces antinociceptive and motor suppressive effects via adenosine receptor activation. PLoS One. 2019 Jun 25;14(6):e0218619. doi: 10.1371/journal.pone.0218619. eCollection 2019.

PubMed ID: 31237895

Pohl J, Ring A, Stremmel W. Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway. J Lipid Res. 2002 Sep;43(9):1390-9. [PubMed]

PubMed ID: 12235170

Atshaves BP, Storey SM, McIntosh AL, Petrescu AD, Lyuksyutova OI, Greenberg AS, Schroeder F. Sterol carrier protein-2 expression modulates protein and lipid composition of lipid droplets. J Biol Chem. 2001 Jul 6;276(27):25324-35. [PubMed]

PubMed ID: 11333258

Milliano MT, Luxon BA. The peroxisomal proliferator clofibrate enhances the hepatic cytoplasmic movement of fatty acids in rats. Hepatology. 2001 Feb;33(2):413-8. [PubMed]

PubMed ID: 11172343

Murphy EJ. Sterol carrier protein-2 expression increases NBD-stearate uptake and cytoplasmic diffusion in L cells. Am J Physiol. 1998 Aug;275(2 Pt 1):G237-43. [PubMed]

PubMed ID: 9688650

Atshaves BP, Foxworth WB, Frolov A, Roths JB, Kier AB, Oetama BK, Piedrahita JA, Schroeder F. Cellular differentiation and I-FABP protein expression modulate fatty acid uptake and diffusion. Am J Physiol. 1998 Mar;274(3 Pt 1):C633-44. [PubMed]

PubMed ID: 9530094

Schroeder F, Myers-Payne SC, Billheimer JT, Wood WG. Probing the ligand binding sites of fatty acid and sterol carrier proteins: effects of ethanol. Biochemistry. 1995 Sep 19;34(37):11919-27. [PubMed]

PubMed ID: 7547928

Luxon BA. Inhibition of binding to fatty acid binding protein reduces the intracellular transport of fatty acids. Am J Physiol. 1996 Jul;271(1 Pt 1):G113-20. [PubMed]

PubMed ID: 8760114

Binding Info

Data was generously provided by Dr. Huan Huang and Dr. Fred Schroeder, Texas A & M University.

Cell Images

Pattern of distribution in living L-cell fibroblasts

NBD-stearate was taken up by L-cells, was not toxic at the low concentrations used, and distributed diffusely throughout the cytoplasm (at low concentrations) and both in the cytoplasm and brightly into lipid droplets (at higher concentrations).


300nM NBD-Stearate, 15min	500nM NBD-Stearate, 15min	20nM Nile Red, 15min

Photos courtesy of Dr. Huan Huang and Dr. Fred Schroeder, Texas A & M University.

Certificates of Analysis

Certificate of Analysis(Lot No. 810110C-1MG-A-010and 5313CGA010)
Certificate of Analysis(Lot No. 810110P-1MG-A-010and 5313PGA010)
Certificate of Analysis(Lot No. 810110P-1MG-B-010and 5313PGB010)
Certificate of Analysis(Lot No. 810110P-1MG-C-010and 5313PGC010)
Certificate of Analysis(Lot No. 810110P-1MG-D-010and 5313PGD010)

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品牌介绍

Avanti Polar Lipids.jpg

Avanti Polar Lipids公司是美国著名的磷脂类产品的生产商，该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供 1000 种以上脂类产品，由于其产品的高纯度而享誉全球。40年来，Avanti Polar Lipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大，其纯度之高也是无人能及。

Avanti Polar Lipids, Inc., has a long history of 50 years creating the highest purity lipids available. Our passion for high quality and unique products is only exceeded by our excellent reputation in the marketplace. Although we are known for our lipids, we are More than Lipids. We offer solutions for the entire product cycle…Research to Commercialization.

Avanti Polar Lipids公司的主要产品和服务包括：

（1）Research Products

Highest Purity Lipid Reagents

（2）cGMP Manufacturing

API & Contract Manufacturing

（3）Adjuvants

Immunotherapy & Vaccine Development

（4）Analytical Services

Lipid Analysis

（5）Lipidomics

Mass Spec Standards, Antibodies & Lipid Toolbox

（6）Formulations