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产品名称：avanti polar lipids/Palmitic acid (15-yne)/5mg/900400P-5mg

产品编号：900400P-5mg

市场价：¥10207.00

场地：美国(厂家直采)

产品分类：生化试剂>生物分子>脂类>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$510.35

品牌： avanti polar lipids

公司：Avanti Lipids Polar, Inc.

公司分类：

商品介绍

900400 | Palmitic acid (15-yne)

15-hexadecynoic acid

Info

Palmitic acid (15-yne)

15-hexadecynoic acid

Alkynyl palmitic acid (aPA) is a modified palmitic acid with an ω-terminal alkyne. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents, known as ‘click chemistry’. The use of aPA in isolating palmitoylated proteins has been described (see References).

Data

Hygroscopic

Light Sensitive

Molecular Formula

C₁₆H₂₈O₂

Percent Composition

C 76.14%, H 11.18%, O 12.68%

Purity

>99%

Stability

1 Years

Storage Temperature

-20°C

CAS Number

99208-90-9 CAS Registry Number is a Registered Trademark of the American Chemical Society

FormulaWeight

252.392

Exact Mass

252.209

Synonyms

aPA

Downloads

ChemDraw File
3D Structure
Structure
Safety Data Sheet

References

Ticho AL, Malhotra P, Manzella CR, Dudeja PK, Saksena S, Gill RK, Alrefai WA. S-Acylation modulates the function of the apical sodium-dependent bile acid transporter in human cells. J Biol Chem. 2020 Feb 18:jbc.RA119.011032. doi: 10.1074/jbc.RA119.011032. Epub ahead of print. PMID: 32071081.

PubMed ID: 32071081

Tallman KA, Armstrong MD, Milne SB, Marnett LJ, Brown HA, Porter NA. Cobalt carbonyl complexes as probes for alkyne-tagged lipids. J Lipid Res. 2013 Mar;54(3):859-68. doi: 10.1194/jlr.D033332. Epub 2013 Jan 10. PMID: 23307946; PMCID: PMC3617960.

PubMed ID: 23307946

Milne SB, Tallman KA, Serwa R, Rouzer CA, Armstrong MD, Marnett LJ, Lukehart CM, Porter NA, Brown HA. Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry. Nat Chem Biol. 2010 Mar;6(3):205-207. doi: 10.1038/nchembio.311. Epub 2010 Jan 24. PMID: 20098428; PMCID: PMC2822082.

PubMed ID: 20098428

Jiang H, Khan S, Wang Y, Charron G, He B, Sebastian C, Du J, Kim R, Ge E, Mostoslavsky R, Hang HC, Hao Q, Lin H. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature. 2013 Apr 4;496(7443):110-3. doi: 10.1038/nature12038. PMID: 23552949; PMCID: PMC3635073.

PubMed ID: 23552949

Thiele C, Papan C, Hoelper D, Kusserow K, Gaebler A, Schoene M, Piotrowitz K, Lohmann D, Spandl J, Stevanovic A, Shevchenko A, Kuerschner L. Tracing fatty acid metabolism by click chemistry. ACS Chem Biol. 2012 Dec 21;7(12):2004-11. doi: 10.1021/cb300414v. Epub 2012 Oct 2. PMID: 22999348.

PubMed ID: 22999348

Gao X, Arenas-Ramirez N, Scales SJ, Hannoush RN. Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes. FEBS Lett. 2011 Aug 4;585(15):2501-6. doi: 10.1016/j.febslet.2011.06.033. Epub 2011 Jul 2. PMID: 21740904.

PubMed ID: 21740904

Yap MC, Kostiuk MA, Martin DD, Perinpanayagam MA, Hak PG, Siddam A, Majjigapu JR, Rajaiah G, Keller BO, Prescher JA, Wu P, Bertozzi CR, Falck JR, Berthiaume LG. Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. J Lipid Res. 2010 Jun;51(6):1566-80. doi: 10.1194/jlr.D002790. Epub 2009 Dec 21. PMID: 20028662; PMCID: PMC3035521.

PubMed ID: 20028662

Martin BR, Cravatt BF. Large-scale profiling of protein palmitoylation in mammalian cells. Nat Methods. 2009 Feb;6(2):135-8. doi: 10.1038/nmeth.1293. Epub 2009 Jan 11. PMID: 19137006; PMCID: PMC2775068.

PubMed ID: 19137006

Certificates of Analysis

Certificate of Analysis(Lot No. 900400P-1MG-A-010and 6377PGA010)
Certificate of Analysis(Lot No. 900400P-5MG-A-010and 6377PHA010)
Certificate of Analysis(Lot No. 900400P-1MG-B-010and 6377PGB010)
Certificate of Analysis(Lot No. 900400P-1MG-B-010and 6377PGB010)
Certificate of Analysis(Lot No. 900400P-5MG-C-010and 6377PHC010)
Certificate of Analysis(Lot No. 900400P-1MG-C-010and 6377PGC010)
Certificate of Analysis(Lot No. 900400P-5MG-D-010and 6377PHD010)

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品牌介绍

Avanti Polar Lipids.jpg

Avanti Polar Lipids公司是美国著名的磷脂类产品的生产商，该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供 1000 种以上脂类产品，由于其产品的高纯度而享誉全球。40年来，Avanti Polar Lipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大，其纯度之高也是无人能及。

Avanti Polar Lipids, Inc., has a long history of 50 years creating the highest purity lipids available. Our passion for high quality and unique products is only exceeded by our excellent reputation in the marketplace. Although we are known for our lipids, we are More than Lipids. We offer solutions for the entire product cycle…Research to Commercialization.

Avanti Polar Lipids公司的主要产品和服务包括：

（1）Research Products

Highest Purity Lipid Reagents

（2）cGMP Manufacturing

API & Contract Manufacturing

（3）Adjuvants

Immunotherapy & Vaccine Development

（4）Analytical Services

Lipid Analysis

（5）Lipidomics

Mass Spec Standards, Antibodies & Lipid Toolbox

（6）Formulations