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产品名称：avanti polar lipids/18:0 DDAB/200mg/890810P-200mg

产品编号：890810P-200mg

市场价：¥5840.00

场地：美国(厂家直采)

产品分类：生化试剂>生物分子>脂类>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$292.00

品牌： avanti polar lipids

公司：Avanti Lipids Polar, Inc.

公司分类：

商品介绍

890810 | 18:0 DDAB

Dimethyldioctadecylammonium (Bromide Salt)

Info

18:0 DDAB

Dimethyldioctadecylammonium (Bromide Salt)

Incorporation of the glycolipid trehalose 6,6"-dibehenate (TDB) into cationic liposomes composed of the quaternary ammonium compound dimethyldioctadecylammonium (DDA) produce an adjuvant system which induces a powerful cell-mediated immune response and a strong antibody response, desirable for a high number of disease targets.

Data

Hygroscopic

Light Sensitive

Molecular Formula

C₃₈H₈₀NBr

Percent Composition

C 72.34%, H 12.78%, Br 12.66%, N 2.22%

Purity

>99%

Stability

1 Years

Storage Temperature

-20°C

CAS Number

3700-67-2 CAS Registry Number is a Registered Trademark of the American Chemical Society

FormulaWeight

630.952

Exact Mass

629.547

Synonyms

dimethyldioctadecylammonium (bromide salt)DDA

Downloads

ChemDraw File
3D Structure
Structure
Safety Data Sheet
Safety Data Sheet

References

Lou G, Anderluzzi G, Tandrup Schmidt S, Woods S, Gallorini S, Brazzoli M, Giusti F, Ferlenghi I, Johnson R, Roberts CW, O"Hagan DT, Baudner BC, Perrie Y. Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection. J Control Release. 2020 Jun 30:S0168-3659(20)30362-X. doi: 10.1016/j.jconrel.2020.06.027. Epub ahead of print. PMID: 32619745.

PubMed ID: 32619745

Lee H, Jiang D, Pardridge WM. Lyoprotectant Optimization for the Freeze-Drying of Receptor-Targeted Trojan Horse Liposomes for Plasmid DNA Delivery. Mol Pharm. 2020 Apr 29. doi: 10.1021/acs.molpharmaceut.0c00310. Epub ahead of print. PMID: 32315188.

PubMed ID: 32315188

Cheng Q, Wei T, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ. Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing. Nat Nanotechnol. 2020 Apr;15(4):313-320. doi: 10.1038/s41565-020-0669-6. Epub 2020 Apr 6. PMID: 32251383.

PubMed ID: 32251383

Chatzikleanthous D, Schmidt ST, Buffi G, Paciello I, Cunliffe R, Carboni F, Romano MR, O"Hagan DT, D"Oro U, Woods S, Roberts CW, Perrie Y, Adamo R. Design of a novel vaccine nanotechnology-based delivery system comprising CpGODN-protein conjugate anchored to liposomes. J Control Release. 2020 Apr 2:S0168-3659(20)30211-X. doi: 10.1016/j.jconrel.2020.04.001. Epub ahead of print. PMID: 32247804.

PubMed ID: 32247804

Larrouy-Maumus G, Layre E, Clark S, Prandi J, Rayner E, Lepore M, de Libero G, Williams A, Puzo G, Gilleron M. Protective efficacy of a lipid antigen vaccine in a guinea pig model of tuberculosis. Vaccine. 2017 Mar 7;35(10):1395-1402. doi: 10.1016/j.vaccine.2017.01.079. Epub 2017 Feb 9. PMID: 28190740.

PubMed ID: 28190740

Derrick SC, Yabe I, Morris S, Cowley S. Induction of Unconventional T Cells by a Mutant Mycobacterium bovis BCG Strain Formulated in Cationic Liposomes Correlates with Protection against Mycobacterium tuberculosis Infections of Immunocompromised Mice. Clin Vaccine Immunol. 2016 Jul 5;23(7):638-47. doi: 10.1128/CVI.00232-16. PMID: 27226281; PMCID: PMC4933783.

PubMed ID: 27226281

Rose F, Wern JE, Ingvarsson PT, van de Weert M, Andersen P, Follmann F, Foged C. Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: A quality-by-design approach. J Control Release. 2015 Jul 28;210:48-57. doi: 10.1016/j.jconrel.2015.05.004. Epub 2015 May 6. PMID: 25957906.

PubMed ID: 25957906

Teng X, Tian M, Li J, Tan S, Yuan X, Yu Q, Jing Y, Zhang Z, Yue T, Zhou L, Fan X. Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine. Hum Vaccin Immunother. 2015;11(6):1456-64. doi: 10.1080/21645515.2015.1037057. PMID: 25905680; PMCID: PMC4514263.

PubMed ID: 25905680

Gallez A, Palazzo C, Blacher S, Tskitishvili E, Noël A, Foidart JM, Evrard B, Pequeux C, Piel G. Liposomes and drug-in-cyclodextrin-in-liposomes formulations encapsulating 17β-estradiol: An innovative drug delivery system that prevents the activation of the membrane-initiated steroid signaling (MISS) of estrogen receptor α. Int J Pharm. 2020 Jan 5;573:118861. doi: 10.1016/j.ijpharm.2019.118861. Epub 2019 Nov 22.

PubMed ID: 31765774

Faria MJ, Machado R, Ribeiro A, Gonçalves H, Real Oliveira MECD, Viseu T, das Neves J, Lúcio M. Rational Development of Liposomal Hydrogels: A Strategy for Topical Vaginal Antiretroviral Drug Delivery in the Context of HIV Prevention. Pharmaceutics. 2019 Sep 18;11(9). pii: E485. doi: 10.3390/pharmaceutics11090485.

PubMed ID: 31540519

Silva AM, Martins-Gomes C, Fangueiro JF, Andreani T, Souto EB. Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines. Pharm Dev Technol. 2019 Sep 11:1-7. doi: 10.1080/10837450.2019.1658774. [Epub ahead of print]

PubMed ID: 31437118

Katayama T, Kinugawa S, Takada S, Furihata T, Fukushima A, Yokota T, Anzai T, Hibino M, Harashima H, Yamada Y. A mitochondrial delivery system using liposome-based nanocarriers that target myoblast cells. Mitochondrion. 2019 Jul 19;49:66-72. doi: 10.1016/j.mito.2019.07.005. [Epub ahead of print]

PubMed ID: 31326598

Yang X, Zhao J, Duan S, Hou X, Li X, Hu Z, Tang Z, Mo F, Lu X. Enhanced cytotoxic T lymphocytes recruitment targeting tumor vasculatures by endoglin aptamer and IP-10 plasmid presenting liposome-based nanocarriers. Theranostics. 2019 May 31;9(14):4066-4083. doi: 10.7150/thno.33383. eCollection 2019.

PubMed ID: 31281532

Patel S, Ryals RC, Weller KK, Pennesi ME, Sahay G. Lipid nanoparticles for delivery of messenger RNA to the back of the eye. J Control Release. 2019 Apr 12;303:91-100. doi: 10.1016/j.jconrel.2019.04.015. [Epub ahead of print]

PubMed ID: 30986436

Marcos K. Masukawa, Cintia C. Vequi-Suplicy, Evandro L.Duarte, M. Teresa Lamy. A closer look into laurdan as a probe to monitor cationic DODAB bilayers. Journal of Photochemistry and Photobiology A: Chemistry. 2019 May 1;376:238-246. doi: 10.1016/j.photochem.2019.03.006

Thakur A, Rodríguez-Rodríguez C, Saatchi K, Rose F, Esposito T, Nosrati Z, Andersen P, Christensen D, Häfeli UO, Foged C. Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization. Front Immunol. 2018 Nov 30;9:2825. doi: 10.3389/fimmu.2018.02825. eCollection 2018.

PubMed ID: 30555488

Oliveira AC, Martens TF, Raemdonck K, Adati RD, Feitosa E, Botelho C, Gomes AC, Braeckmans K, Real Oliveira ME. Dioctadecyldimethylammonium:monoolein nanocarriers for efficient in vitro gene silencing. ACS Appl Mater Interfaces. 2014 May 14;6(9):6977-89. doi: 10.1021/am500793y. Epub 2014 Apr 18.

PubMed ID: 24712543

Zhu N, Liggitt D, Liu Y, Debs R. Systemic gene expression after intravenous DNA delivery into adult mice. Science. 1993 Jul 9;261(5118):209-11.

PubMed ID: 7687073

Bicelle Preparation

Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation. Reference/Protocol

Certificates of Analysis

Certificate of Analysis(Lot No. 890810C-200MG-A-029and 6353CNA029)
Certificate of Analysis(Lot No. 890810C-25MG-A-029and 6353CJA029)
Certificate of Analysis(Lot No. 890810P-1G-A-029and 6353PQA029)
Certificate of Analysis(Lot No. 890810P-200MG-A-029and 6353PNA029)
Certificate of Analysis(Lot No. 890810P-25MG-A-029and 6353PJA029)
Certificate of Analysis(Lot No. 890810P-500MG-A-029and 6353PPA029)
Certificate of Analysis(Lot No. 890810P-1G-B-029and 6353PQB029)
Certificate of Analysis(Lot No. 890810P-25MG-B-029and 6353PJB029)
Certificate of Analysis(Lot No. 890810P-200MG-B-029and 6353PNB029)
Certificate of Analysis(Lot No. 890810P-1G-C-029and 6353PQC029)
Certificate of Analysis(Lot No. 890810C-25MG-B-029and 6353CJB029)
Certificate of Analysis(Lot No. 890810P-1G-D-029and 6353PQD029)
Certificate of Analysis(Lot No. 890810P-200MG-C-029and 6353PNC029)
Certificate of Analysis(Lot No. 890810P-200MG-D-029and 6353PND029)
Certificate of Analysis(Lot No. 890810P-200MG-E-029and 6353PNE029)
Certificate of Analysis(Lot No. 890810P-1G-E-029and 6353PQE029)
Certificate of Analysis(Lot No. 890810P-200MG-A-030and 6353PNA030)
Certificate of Analysis(Lot No. 890810C-25MG-A-030and 6353CJA030)
Certificate of Analysis(Lot No. 890810C-200MG-A-030and 6353CNA030)
Certificate of Analysis(Lot No. 890810P-200MG-B-030and 6353PNB030)
Certificate of Analysis(Lot No. 890810P-25MG-C-030and 6353PJC030)
Certificate of Analysis(Lot No. 890810P-1G-B-030and 6353PQB030)
Certificate of Analysis(Lot No. 890810P-25MG-D-030and 6353PJD030)

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品牌介绍

Avanti Polar Lipids.jpg

Avanti Polar Lipids公司是美国著名的磷脂类产品的生产商，该公司主要为各种制药厂和研究机构提供从毫克级到公斤级乃至吨级的磷脂类和甾体类中间体和试剂。为世界范围内的研究机构和制药公司提供 1000 种以上脂类产品，由于其产品的高纯度而享誉全球。40年来，Avanti Polar Lipids公司为世界各地的研究人员和制药公司提供脂类产品。公司的产品不仅范围日益扩大，其纯度之高也是无人能及。

Avanti Polar Lipids, Inc., has a long history of 50 years creating the highest purity lipids available. Our passion for high quality and unique products is only exceeded by our excellent reputation in the marketplace. Although we are known for our lipids, we are More than Lipids. We offer solutions for the entire product cycle…Research to Commercialization.

Avanti Polar Lipids公司的主要产品和服务包括：

（1）Research Products

Highest Purity Lipid Reagents

（2）cGMP Manufacturing

API & Contract Manufacturing

（3）Adjuvants

Immunotherapy & Vaccine Development

（4）Analytical Services

Lipid Analysis

（5）Lipidomics

Mass Spec Standards, Antibodies & Lipid Toolbox

（6）Formulations